Once discarded as waste, whey has newfound value, thanks to its versatile proteins—and some creative ideas about using them.

FOR JESSICA ZIMMERMAN, a fifth-grader at Northside Elementary School in Middleton, Wis., lunch is the most trying meal of the day. Because of a rare genetic condition that makes protein act like poison inside her body, Jessica can’t eat most of the things fifth-graders eat: no hot dogs, no chicken strips, no eggs, milk or cheese. If she were to eat any of these foods, an amino acid called phenylalanine would collect in her bloodstream and travel straight to her brain, where it would cause her to lose concentration on her studies and play havoc with her emotions. 5 Instead, Jessica follows a prescribed diet stricter than any vegan’s. A typical packed lunch includes a sandwich of artificial cheese on homemade, protein-free bread, a piece of fruit and mineral water. But the really awful part is what she must drink: a foul-smelling , milky-white beverage that provides virtually all of her dietary protein. Blended fresh daily by her mother, Ann, the beverage is a cocktail of amino acids specially designed for people with Jessica’s condition, known as phenylketonuria, or PKU. Jessica drinks this concoction three times a day, even though she hates the way it tastes and how it makes her breath smell. At school, kids sometimes teased her for drinking “ baby formula,” and now she refuses to drink it there, opting to wait until she gets home. But without her mid-day dose of amino acids, Jessica’s mind drifts in afternoon classes.

“Controlling Jessica’s phenylalanine levels poses constant dilemmas no kid should have to face,” Ann Zimmerman says. “A small Rice Krispie treat or a small order of French fries is a rare delight, which requires Jessie to be extra diligent that day. She never gets a day off. Not on her birthday, not on Halloween, not on Christmas.”

It’s unfair, Ann thinks, that food could be so cruel.

IN A LABORATORY-CUM-KITCHEN in Babcock Hall, Kathy Nelson, a researcher at the Wisconsin Center for Dairy Research, measures ingredients on a digital scale before throwing them in a mixing bowl. She’s making a batch of strawberry pudding, her favorite in a line of foods she designed for Jessica Zimmerman and others with PKU. These items may soon be the first protein-rich foods Jessica ever eats.

The reason? Nelson’s foods contain a secret ingredient: a unique protein derived from whey, the liquid byproduct of cheesemaking.

For the 15,000 people in the United States with PKU, protein is usually a problem because their bodies lack the enzyme responsible for breaking down phenylalanine, one of the 20 major amino acids that form proteins. All of the proteins we eat in everyday foods contain phenylalanine, and because of that, diet is a chore for people with PKU. A little phenylalanine is essential. But excess amounts can stay in the body indefinitely and interfere with brain function. Too much phenylalanine leads to “an inability to concentrate and focus,” says Sally Gleason, a nutritional counselor and case manager who works with individuals with PKU at UW-Madison’s Waisman Center, one of the nation’s premier centers for PKU research. “ They also face emotional problems and depression.” The only solution for Jessica is to heavily supplement her diet with the amino-acid shake, which is specially formulated to exclude phenylalanine.

In the late 1990s, however, CALS food scientist Mark Etzel found another option: a protein known as glycomacropeptide. GMP turns out to be the only dietary protein in nature that doesn’t contain phenylalanine. And the only place you can find GMP is in whey, which is produced when milk curdles to form cheese curds. Working for the WCDR, a largely farmer-funded organization dedicated to supporting the dairy industry, Etzel developed a method to isolate and purify large quantities of GMP from whey, some 22 billion pounds of which are generated by Wisconsin’s cheese plants ever y year. In fact, for every one pound of cheese, dairy plants end up with nine pounds of whey.

Despite seemingly limitless quantities of it, the protein in liquid whey is too dilute to be of significant nutritional value as is. It’s also full of fats, sugars and minerals that are less than ideal for human consumption, Miss Muffet aside. For years, cheesemakers have done little with this haul other than throw it on their fields or feed it to pigs.

“The point of (Etzel’s project) was to find something special in whey, a waste product that we literally have tons of here in Wisconsin,” says Denise Ney, a CALS nutritional scientist who studies the effect of GMP on the body. “And he found it.”

Whey’s rags-to-riches story traces to the 1970s, when researchers began perfecting the technologies to isolate and purify its proteins, for the first time making it possible to use them to enrich other foods. Bodybuilders were the first to catch on: in the 1980s, they recognized the utility of whey protein to help muscles recover from strenuous workouts, and their enthusiasm for the product helped it enter the mainstream. Soon, energy bars and sports drinks began including whey protein as a chief ingredient. One of those drinks, formulated by the WCDR and produced by the Babcock Hall dairy plant, is now consumed by athletes on the Badger football, basketball and hockey teams after workouts—a Wisconsin version of Gatorade that goes by the utilitarian name of Recovery Drink.

“It’s been great for us,” says Ben Herbert, assistant strength and conditioning coach for the UW football team. “A lot of these supplements don’t taste very good. This gives us what we need, and the guys really like to drink it.”But whey protein is also present in an astonishing number of everyday foods, from ice cream to infant formula (see graphic, below).

This proliferation of uses has, for the most part, been a boon for the dairy industry. Unprecedented global demand drove the price of dried whey to a record high of 78 cents per pound last April, more than triple its long-term average.

This increase has been a significant factor behind the rising price farmers receive for milk, says Brian Gould, a professor of agricultural and applied economics. “For every 10-cent increase in the price of dried whey, the class III milk price increases by 60 cents,” explains Gould. In Wisconsin, where a vast majority of the milk is class III milk—the type used for making cheese—most farmers received a 20 percent raise over their 2006 earnings thanks to whey.

Etzel says one reason for the boom is the versatility of dairy proteins. “One of the nice things about dairy proteins is that because cows are mammals, like humans are, they have a lot of biological functions in humans that you wouldn’t find in a plant protein, like soy,” he says.

Previously, he developed a method to purify lactoferrin, a protein found in whey and human breast milk that is known to boost immunity in children and cancer patients. To help find uses for GMP, “we have medical doctors, health care professionals, food-product developers, nutritional scientists and then me working on protein purification.”

It’s that broad approach that gave Etzel the opportunity to meet patients with PKU, which he says was a transformative moment in his career. “It’s so rare when you are doing basic science that you come in contact with people who are suffering that you can help,” he says.

IN THE PAST, babies born with PKU became mentally disabled before anything could be done to help them. Unable to process the proteins in breast milk, infants with PKU were inadvertently poisoned by their mothers’ milk practically from day one. With the advent of genetic screening in the 1960s, doctors are able to identify the condition with a simple blood test and quickly intervene. Breast-feeding is replaced by bottles of special formula—a baby’s version of the amino-acid cocktail that Jessica Zimmerman drinks every day. “Jessica was born on a Saturday,”
recalls Ann Zimmerman. “She was on diet the following Thursday.”

To ensure that she is not getting too much phenylalanine, ever y item that crosses Jessica’s lips must be measured and recorded in a food diary. In a culture that often revolves around food, she is a forced bystander. “Everywhere you go there’s food,” says her mother. “ That’s one thing you start to notice right away. For instance, if someone shows up at soccer practice with cupcakes, and I have nothing to give Jessie, she has to say, ‘That’s okay,’ and then sit there and watch them all eat it. That is the hardest part, if you ask me, the total lack of spontaneity.”

Ann Zimmerman is also concerned with her daughter’s approaching teen years, when kids naturally rebel against rules. Just as their peers may feel the temptation of cigarettes or alcohol, PKU teens can succumb to the allure of illicit foods. Normally, going off-diet at this age causes only temporary problems, but on rare occasions, a teenager’s indiscretions can lead to permanent brain damage.

And along with worries come daily hassles and headaches. To make Jessica’s formula, the family must pack a blender, pitcher and special cup, as well as a large container of powdered amino acids. The latter always raises questions from airport security guards, even though the family carries a doctor’s note explaining Jessica’s condition. Being able to meet Jessica’s needs with a pudding cup or granola bar made with GMP “would be so welcome,” says Ann Zimmerman.
“It would really free people up and give them more independence.” Short of a treatment or cure for the underlying condition, it’s what parents like her want the most for their kids: to experience the pleasure of eating.

That’s where Kathy Nelson comes in. Before joining the Wisconsin Center for Dairy Research, she spent ten years developing desserts at Pillsbury, and her role is to be part researcher and part foodie, creating new products that will be pleasing to consumers.

In 2001, Nelson turned her attention to improving the PKU diet. She began experimenting with GMP, but her first attempt at a GMP-fortified food, a loaf of bread, failed. “ The more protein I added, the worse the bread turned out. The loaf would just collapse,” she says.

During the next three years, however, Nelson created crackers, fruit leather, chocolate and strawberry pudding, and two types of drinks using GMP. A small sample of PKU patients are currently testing those foods, replacing their amino acid drinks with GMP foods for a four-day trial. Ten patients have completed the trials, and early results have confirmed that GMP foods re safe and well-accepted.

According to Denise Ney, the UW- Madison professor of nutritional science who heads up the study, the ultimate goal isn’t to replace the amino acid drink entirely, but simply to develop some safe, tasty and convenient alternatives.

“I think GMP could replace about 50 percent of the amino acid drink,” she says. “Most people take two to three cups per day. In the future, maybe they would only have to take one or two cups er day, and just have some GMP pudding instead.”

Already, Cambrooke Foods, a Massachusetts company that manufactures low-protein foods for the PKU diet, is moving for ward with the production of two GMP-fortified snack items, including Nelson’s chocolate pudding.

Meanwhile, longer-term research is exploring whey’s role in fighting some of the country’s biggest health problems. Recent scientific studies show that whey may help lower blood pressure, help patients with early-stage diabetes manage their glucose and insulin levels, and help dieters control their hunger. K.J. Burrington BS’84 MS’87, the WCDR researcher who formulated the Babcock Recovery Drink for the Badger athletics team, sees a possibility that the same drink that bulks up football players could help trim America’s ballooning waistline.

“It gives you a feeling of fullness,” she says. “It also helps you maintain muscle mass while losing fat.”

Beyond its food applications, whey also is proving to be a good feedstock for biofuel production. Its sugars can be turned into ethanol in a process that is cheaper than making the fuel from corn ernels. In consideration of these emerging uses, some dairy economists have even speculated that whey could eventually become the most valuable part of cheese, meaning that one day cheese might be made for the prime reason of generating whey. That’s a dramatic turnaround from the days of dumping the stuff down the drain. And for farmers, researchers and even a certain fifth-grade girl, that’s the whey they like it. Download Full PDF of A Whole New Whey